abstract：:After axotomy of embryonic hippocampal neurons in vitro, some of the axotomized axons lose their identity, and new axons arise and grow. This axotomy-induced axonogenesis requires importin, suggesting that some injury-induced signals are transported via axons to elicit axonogenesis after axotomy. In this study, we sho...

journal_title：Cell death & disease

authors： Ohara R,Fujita Y,Hata K,Nakagawa M,Yamashita T

更新日期：2011-06-23 00:00:00

abstract：:Alzheimer's disease (AD) is pathologically characterised by the age-dependent deposition of β-amyloid (Aβ) in senile plaques, intraneuronal accumulation of tau as neurofibrillary tangles, synaptic dysfunction and neuronal death. Neuroinflammation, typified by the accumulation of activated microglia and reactive astroc...

journal_title：Cell death & disease

authors： Garwood CJ,Pooler AM,Atherton J,Hanger DP,Noble W

更新日期：2011-06-02 00:00:00

abstract：:Lipid rafts and mitochondria are promising targets in cancer therapy. The synthetic antitumor alkyl-lysophospholipid analog edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) has been reported to target lipid rafts. Here, we have found that edelfosine induced loss of mitochondrial membrane potential an...

journal_title：Cell death & disease

authors： Mollinedo F,Fernández M,Hornillos V,Delgado J,Amat-Guerri F,Acuña AU,Nieto-Miguel T,Villa-Pulgarín JA,González-García C,Ceña V,Gajate C

更新日期：2011-05-19 00:00:00

abstract：:Aggregatibacter (Actinobacillus) actinomycetemcomitans is a facultative anaerobic gram-negative bacterium associated with severe forms of periodontitis. A leukotoxin, which belongs to the repeats-in-toxin family, is believed to be one of its virulence factors and to have an important role in the bacterium's pathogenic...

journal_title：Cell death & disease

authors： Kelk P,Abd H,Claesson R,Sandström G,Sjöstedt A,Johansson A

更新日期：2011-03-10 00:00:00

abstract：:The injurious consequences of ionizing radiation (IR) to normal human cells and the acquired radioresistance of cancer cells represent limitations to cancer radiotherapy. IR induces DNA damage response pathways that orchestrate cell cycle arrest, DNA repair or apoptosis such that irradiated cells are either repaired o...

journal_title：Cell death & disease

authors： Kumar A,Oskouian B,Fyrst H,Zhang M,Paris F,Saba JD

更新日期：2011-02-10 00:00:00

abstract：:Direct pharmacological targeting of the anti-apoptotic B-cell lymphoma-2 (BCL-2) family is an attractive therapeutic strategy for treating cancer. Obatoclax is a pan-BCL-2 family inhibitor currently in clinical development. Here we show that, although obatoclax can induce mitochondrial apoptosis dependent on BCL-2 ass...

journal_title：Cell death & disease

authors： McCoy F,Hurwitz J,McTavish N,Paul I,Barnes C,O'Hagan B,Odrzywol K,Murray J,Longley D,McKerr G,Fennell DA

更新日期：2010-12-16 00:00:00

abstract：:Our previous studies have shown that microRNA-383 (miR-383) expression is downregulated in the testes of infertile men with maturation arrest (MA). However, the underlying mechanisms of miR-383 involved in the pathogenesis of MA remain unknown. In this study, we showed that downregulation of miR-383 was associated wit...

journal_title：Cell death & disease

authors： Lian J,Tian H,Liu L,Zhang XS,Li WQ,Deng YM,Yao GD,Yin MM,Sun F

更新日期：2010-11-04 00:00:00

abstract：:Proton pump inhibitors (PPI) target tumour acidic pH and have an antineoplastic effect in melanoma. The PPI esomeprazole (ESOM) kills melanoma cells through a caspase-dependent pathway involving cytosolic acidification and alkalinization of tumour pH. In this paper, we further investigated the mechanisms of ESOM-induc...

journal_title：Cell death & disease

authors： Marino ML,Fais S,Djavaheri-Mergny M,Villa A,Meschini S,Lozupone F,Venturi G,Della Mina P,Pattingre S,Rivoltini L,Codogno P,De Milito A

更新日期：2010-10-21 00:00:00

abstract：:Apoptotic cysteine-aspartate proteases (caspases) are essential for the progression and execution of apoptosis, and detection of caspase fragmentation or activity is often used as markers of apoptosis. Cisplatin (cis-diamminedichloroplatinum (II)) is a chemotherapeutic drug that is clinically used for the treatment of...

journal_title：Cell death & disease

authors： Janson V,Johansson A,Grankvist K

更新日期：2010-09-23 00:00:00

abstract：:Evidence is mounting that proinflammatory and proapoptotic thioredoxin-interacting protein (TXNIP) has a causative role in the development of diabetes. However, there are no studies investigating the role of TXNIP in diabetic retinopathy (DR). Here, we show that, in diabetic rats, TXNIP expression and hexosamine biosy...

journal_title：Cell death & disease

authors： Perrone L,Devi TS,Hosoya KI,Terasaki T,Singh LP

更新日期：2010-08-19 00:00:00

abstract：:Histone deacetylases (HDACs) are epigenetic regulators that are important for the control of various pathophysiological events. We found that HDAC inhibitors completely abolished transforming growth factor-β1 (TGF-β1)-induced apoptosis in AML-12 and primary mouse hepatocytes. Expression of a dominant-negative mutant o...

journal_title：Cell death & disease

authors： Lei WW,Zhang KH,Pan XC,Wang DM,Hu Y,Yang YN,Song JG

更新日期：2010-05-20 00:00:00

abstract：:Homeostatic chemokines, such as CXCL12, can affect neuronal activity by the regulation of inhibitory and excitatory neurotransmission, but the mechanisms involved are still undefined. Our previous studies have shown that CXCL12 protects cortical neurons from excitotoxicity by promoting the function of the gene-repress...

journal_title：Cell death & disease

authors： Nicolai J,Burbassi S,Rubin J,Meucci O

更新日期：2010-04-01 00:00:00

abstract：:The 37/67 kDa laminin receptor (LAMR) is a multifunctional protein, acting as an extracellular receptor, localizing to the nucleus, and playing roles in rRNA processing and ribosome assembly. LAMR is important for cell viability; however, it is unclear which of its functions are essential. We developed a silent mutant...

journal_title：Cell death & disease

authors： Scheiman J,Jamieson KV,Ziello J,Tseng JC,Meruelo D

更新日期：2010-01-01 00:00:00

abstract：:Natural-food-based compounds show substantial promise for prevention and biotherapy of cancers including leukemia. In general, their mechanism of action remains unclear, hampering rational use of these compounds. Herein we show that the common dietary flavonoid apigenin has anticancer activity, but also may decrease c...

journal_title：Cell death & disease

authors： Ruela-de-Sousa RR,Fuhler GM,Blom N,Ferreira CV,Aoyama H,Peppelenbosch MP

更新日期：2010-01-01 00:00:00

abstract：:Transplantation of neural progenitors derived from human embryonic stem cells (hESCs) provides a potential therapy for ischemic stroke. However, poor graft survival within the host environment has hampered the benefits and applications of cell-based therapies. The present investigation tested a preconditioning strateg...

journal_title：Cell death & disease

authors： Francis KR,Wei L

更新日期：2010-01-01 00:00:00